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Watch Carefully (one)mitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Mitotane is a robust inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for probable dosage changes.If this SPL has inactivated NDCs shown because of the FDA initiated complian